Put several crib sheets on at the same time
Sara offers this excellent crib-making advice, which I can attest to, having recently dealt with a bout of stomach flu around here. Sigh.
In those first months, when you find yourself changing crib sheets a couple times a night, consider making the bed with 2 or 3 layers of sheets and sheet protectors. That way, when it is 3 o'clock in the morning and the sheets are soiled all you have to do is pull of the top layer and you're good to go.
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